Development and validation of an HPLC–MS/MS method to determine clopidogrel in human plasma
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چکیده
منابع مشابه
Development and validation of an HPLC–MS/MS method to determine clopidogrel in human plasma
A quantitative method for clopidogrel using online-SPE tandem LC-MS/MS was developed and fully validated according to the well-established FDA guidelines. The method achieves adequate sensitivity for pharmacokinetic studies, with lower limit of quantifications (LLOQs) as low as 10 pg/mL. Chromatographic separations were performed on reversed phase columns Kromasil Eternity-2.5-C18-UHPLC for bot...
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A rapid, sensitive and reproducible HPLC method was developed and validatedfor the analysis of amifostine (AMF) and/or its metabolite, WR-1065 inhuman plasma. The method involves the alkylation of free sulfydryl group with iodoacetic acid followed by derivatization of the drug and its metabolite witho-phthaldialdehyde (OPA) andUVdetection at 340 nm. The derivatized AMF and WR-1065 were eluted i...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2016
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2015.11.001